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Further detailed studies to understand the interplay of various components will be needed in order to improve the systemic and/or local exposure of beneficial UGT substrates
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Interestingly, mice lacking TNFR2 displayed a loss of CXCL12 up-regulation in astrocytes and concomitant reduction in the number of NG2- CXCR4-positive OPC leading to delayed remyelination in the cuprizone model (Patel et al., 2012)
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