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These results show that the HAW oral treatment, together with restoring the ROS levels at both the systemic and organ levels, led to the normalization of both the mitochondrial membrane potential and the mitochondrial superoxide levels induced by H 2 O 2 treatment, reaching levels comparable to the control mice
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After genomic incorporation, AzadC is recognized by DNMTs as dC, but because of the CH-N replacement at the pyrimidine ring, DNMTs cannot be released anymore after the nucleophilic attack, resulting in permanent crosslinks between the protein and the 5-aza-cytosine nucleobase (1) (Fig 1A)
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