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2 a selective small-molecule NNMT inhibitor, 5-Amino-1MQ, reduced fat mass and improved metabolic markers in obese mice over days to weeks, apparently by raising fat-cell energy expenditure rather than curbing appetite
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Similar to what is observed in brain, mitochondria isolated from peripheral AD and MCI lymphocytes support the oxidation glycolytic enzymes, such as Eno1, suggesting its importance as a potential biomarker for MCI and AD (323)
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