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Available randomized controlled trials have used a high dose of multivitamin supplements and cancer was the unplanned outcome, thus the causality of B12 in cancer cannot be judged based on these trials
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JAK2 V617F is found in approximately 50% of ET and PMF patients, but JAK2 V617F allele burden is usually higher in PV than ET patients [23, 24] and JAK2 V617F- positive ET patients generally have higher hemoglobin and lower platelet counts as compared to JAK2 V617F -negative ET patients [25, 26]
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