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N Engl J Med 2012;367, 795-804, doi:10.1056/NEJMoa1202753
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Additionally, during the CORT process, the number and structural abnormalities of GR (excessive beta structure and insufficient alpha structure) and imbalanced expression of 11β-HSD (excessive 11β-HSD1 and insufficient 11β-HSD2) prevent the anti-inflammatory effects of CORT, contributing to GC resistance in immunotherapy
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