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This limitation is likely a major factor preventing curcumin’s clinical approval as a treatment for medical conditions, despite evidence supporting its safety at doses as high as 12 grams per day (20)

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N-acetylcysteine (NAC) is a compound that provides cysteine — the amino acid that’s often the limiting factor in glutathione synthesis.¹,¹³,¹⁴ It’s commonly discussed in wellness conversations as a glutathione precursor