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Multiple sequence alignment was performed using Clustal Omega ( D seg and B LC were calculated with the equation described in Supplementary Note
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Purkinje cells, dorsal column neurons, and cardiomyocytes all exhibit ferroptotic features in FRDA, yet this study does not distinguish pathway differences across organs—for example, whether cerebellar injury depends more on ACSL4-mediated lipid dysregulation and whether cardiomyocyte vulnerability primarily reflects GPX4 inactivation
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