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On observa que les patients souffrant d’anémie pernicieuse amélioraient leur état avec la consommation de foie, puis avec l’administration d’extraits concentrés issus de foies animaux, qui furent utilisés pendant des années comme traitement de référence, jusqu’à ce qu’on identifie la vitamine B12 comme l’élément actif responsable de ces effets, ce qui permit de développer sa synthèse isolée, réalisée vers le milieu du XXe siècle
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Review of cobalamin status and disorders of cobalamin metabolism in dogs
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