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Additionally, PD-1 can not only inhibit T lymphocyte activation and accelerate T lymphocyte apoptosis but can also be regulated by molecules in the TME, such as TGF-β, IL-7, IL-15, IL-21 and IFN-α (Kinter et al., 2008
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Many individuals with amnestic MCI develop AD, suggesting MCI is the earliest stage of AD [29
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