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The fact that the cell cycle arrest and cell size increase have opposing effects on Era2-induced ferroptosis susceptibility could explain why different studies reported seemingly contradictory results, where sometimes an increased and sometimes a decreased or unchanged sensitivity to system x c - inhibitors was observed depending on the cell type, duration and type of cell cycle arrest (Lee et al, 2024
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Activity measurements for each respiratory chain complex in permeabilized cells were performed according to previous research 85,138
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