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survodutide and mazdutide Amylin biology: pramlintide and cagrilintide co-agonist strategies Melanocortin-pathway obesity pharmacology and defined genetic indications (setmelanotide) Compounded versus branded supply: what changed, what the pharmacy can legally supply, and what to document Dose-equivalence errors, unit-versus-milligram confusion and the reported harm patterns 3.3Body Composition, Muscle Preservation & Metabolic Assessment Body-composition measurement: DEXA, BIA, circumference and photographic standards Lean-mass loss during rapid weight reduction and what the trial data actually report Protein targets, resistance-training prescription and the evidence behind each Adjuncts studied for lean-mass preservation and the strength of that evidence (GH-axis agents, bimagrumab, SARMs as context) Resting metabolic rate, adaptive thermogenesis and plateau physiology Sarcopenia screening and the older adult on an incretin Bone density considerations during sustained caloric restriction 3.4Titration, Tolerability & Adverse-Effect Management Structured titration schedules and when to hold, reduce or extend an interval Nausea, vomiting, constipation, diarrhea and reflux: stepwise management algorithms Gastroparesis, ileus and the presentations that require imaging or referral Pancreatitis and gallbladder events: screening, counseling and workup thresholds Thyroid C-cell and MEN2 contraindications