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Matrix metalloproteinase-9 activation in hyperhomocysteinemic rats is triggered by the opening of the mitochondrial permeability transition pore and antagonism of the N-methyl-D-aspartate receptor-1 (NMDA-R1), resulting in myocyte dysfunction due to elevated calcium overload and oxidative stress [40]
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Standalone B12 makes sense mainly when you're treating a confirmed deficiency under provider guidance and need a higher repletion dose
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