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Single-cell metabolomics and spatial transcriptomics should be employed in future research to unravel the metabolic heterogeneity within different synovial cell populations (FLSs, macrophage subsets, T cell subsets, B cells, and endothelial cells) and metabolic crosstalk between them under dynamic disease states (early established RA, remission, and onset)
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Ma et al., 2018)
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