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Extrinsic factors, particularly photoaging from UV radiation, amplify these mechanisms by reducing TGF-Ξ² receptor II (TΞ²RII) and Smad signaling, leading to downregulation of CTGF and type I procollagen, thereby suppressing collagen synthesis (Quan et al, 2004)
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Clinical applications of exosomes Abbreviations dTGN dispersed trans-Golgi network GvHD graft-versus-host disease HucMSCs human umbilical cord MSCs MHC-I major histocompatibility complex type 1 MSC-EVs MSC-derived extracellular vesicles MSC-Exos mesenchymal stem cell-derived exosomes NASH nonalcoholic steatohepatitis NLRP3 nucleotide-binding domain RNS reactive nitrogen radicals TGF-Ξ² transforming growth factor Ξ² UCMSCs umbilical cord-derived MSCs REFERENCES 1
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