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KPT-9274 P21 activated kinase 4 (PAK4) plays a critical role in various signaling pathways in cancer, including the Wnt/β-catenin, RAS-ERK, and androgen/estrogen receptor pathways [189]
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In vivo animal experiments showed that daily administration of NNMTi for 28 days to diet‑induced obese (DIO) mice significantly upregulated the expression of lipolysis‑related genes (such as ATGL and HSL) and downregulated lipogenesis‑related genes (such as FAS and ACC), indicating that NNMTi effectively promotes fat breakdown and inhibits fat synthesis
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