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Glutathione peroxidase 4 (GPx4), is the only enzyme in cells that can reduce lipid peroxides to normal phospholipid molecules, its activity is crucial for maintaining normal cell function and ferroptosis [74]
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Another study found that GLT-1 loss led to a compensatory increase in insulin-degrading enzyme activity in the liver, implicating partial GLT-1 loss in insulin/Akt signaling abnormalities observed in AD [238]
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