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Indeed, FLNA can bind many different partner proteins, including transmembrane proteins, such as several GPCRs, integrins, and ion channels, allowing their anchorage to actin cytoskeleton (75), but also intracellular signaling molecules, kinases, and transcription factors [revised in Ref
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Barrier breakdown allows more allergens in, which triggers more Th2 activation, which further weakens the barrier
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