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Integrated stress response (ISR) A stress response pathway that responds to various cellular insults, including amino acid deprivation, through the GCN2 kinase, to phosphorylate eIF2α halt general cap-dependent protein translation, and increase transcription of endoplasmic reticulum chaperone proteins
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Mechanistic research should be deepened by integrating multi-omics approaches such as metagenomics, metabolomics, and transcriptomics to systematically elucidate the structure-activity relationships of TCMPs and their “microbiota-metabolite-immunity” regulatory networks
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