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The results showed that maternal RPM supplementation in late gestation promoted more significant global DNA methylation in the offspring’s liver, accompanied by a general alteration in the hepatic transcriptome, proteome, and metabolome, favoring the enrichment in glucose and lipid metabolism, glutathione, and immune system pathways (Palombo et al., 2021)
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In WD, mutations in the ATP7B gene disrupt CP synthesis and biliary copper excretion, resulting in hepatic copper accumulation, neurotoxicity, and reduced serum copper levels[28]
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