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As mentioned previously, mast cells and keratinocytes can induce vascularization through the increment in VEGF secretion, enhanced TGF-β and FGF-2, thus can create more, larger, and highly dilated vessels which are considered important targets in melasma treatment (Kim et al., 2005
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In RA, rapamycin inhibits proliferation and induces apoptosis of fibroblast-like synoviocytes via the AKT/mTORC1 pathway, reducing joint inflammation and tissue damage
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